Laboratoire Génétique Reproduction et Développement GReD. CNRS / Université Clermont Auvergne
Clermont Ferrand, France
We are using drosophila as a model to gain insights into normal and pathological blood cell development, with a particular focus on transcriptional regulators whose homologs are mutated in leukemia.
We are interested in the normal and pathological development of blood cells. Using Drosophila as an in vivo model system, our aim is to decipher the conserved gene regulatory networks that are employed at different steps of hematopoiesis from blood cell commitment to terminal differentiation. We are particularly focusing our study on the mode of action of GATA and RUNX transcription factors (as well as some human leukemogenic proteins) during this process. Finally, we try to understand the intricate relationships between the hematopoietic niche, the blood cell progenitors and their differentiated progenies during normal development and in different stress situations.
22510984, 22411814, 21377624, 20368357, 20540764, 19581587
drosophila, hematopoiesis, leukemia, transcription, cancer
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