thomas vaccari

@vaccart
active 10 months, 2 weeks ago
Hey guys, the bioarxiv paper is now out (with a couple of mods thanks to tips of Jedi master Schweisguth :-)). Here’s the link: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0093987 View

Base

Full Name

thomas vaccari

Current position

group leader

Affiliation

IFOM – FIRC Institute of Molecular Oncology

Location

Milan, Italy

Research interests

Our interest is to decipher how endocytosis controls signal transduction, with particular emphasis on Notch signaling and tumor suppression

Webpage

http://www.ifom-ieo-campus.it/research/vaccari.php

Twitter handle

@vaccart

Google Scholar Profile

http://scholar.google.com/citations?user=HguUP9UAAAAJ&hl=en

Research activity

Research

Acidify, Fuse and Sort: uncovering how trafficking regulators suppress tumors –>
Defects in intracellular trafficking are increasingly associated to cancer. Interestingly, certain endocytic genes act as tumor suppressors in flies by preventing the formation of tumors which display several hallmarks of cancer. One of the processes conferring tumor suppressive activity to endocytic genes in flies is their ability to hold Notch signaling in check. Indeed, transduction of Notch signals is coupled to receptor trafficking and degradation in endosomes. Such coupling is lost in ESCRT mutants which display aberrant Notch signaling. Despite this, the mechanisms underlying the tumor suppressive role of trafficking remain largely unknown. We are convinced that the understanding of the endocytic mechanisms that control signaling, tissue growth and tissue architecture will lead to development of new and more effective anticancer treatments.

Representative publications

20460366, 19560990, 18299346, 16256743

Research keywords

Signaling,
Notch,
ESCRT,
V-ATPase,
Tumor suppression,
Cell growth,
Tissue architecture,
Development

Job openings

We are always on the look for good postdocs. Send a mail if interested 🙂

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Latitude and Longitude

45.444221496582,9.20303916931152