Thomas Flatt

@tflatt
active 1 week, 4 days ago
We have just recently published a new paper on genome-wide patterns of latitudinal differentiation in Drosophila melanogaster, using pool-seq, in Molecular Ecology: Fabian DK, Kapun M, Nolte V, Kofler R, Schmidt PS, Schlötterer C, Flatt T. 2012. “Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster […] View

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Full Name

Thomas Flatt

Current position

Professor

Affiliation

Department of Biology, University of Fribourg

Location

Fribourg, Switzerland

Research interests

I study the genetic and physiological mechanisms underlying the evolution of life history traits, with a particular emphasis on lifespan and aging, using Drosophila melanogaster as a model system.

Webpage

http://www.unifr.ch/biology/research/flatt/

Twitter handle

@FlattLab

Google Scholar Profile

https://scholar.google.ch/citations?user=hnOIPdEAAAAJ&hl=en

Research activity

Research

I study the genetic and physiological mechanisms underlying the evolution of life history traits, with a particular emphasis on lifespan and aging. How do life history traits evolve, within and among species, to generate phenotypic variation? What are the mechanisms underlying life history plasticity and trade-offs? One central focus of my research is on understanding how hormonal signaling pathways (e.g., insulin, juvenile hormone, and ecdysone) affect the phenotypic expression and evolution of aging and trade-offs between reproduction and lifespan, immune function, and somatic maintenance. Another focus of my work is on understanding the genetic basis of evolutionary changes in lifespan and other life history traits in natural and laboratory populations. To address these problems I combine the tools of evolutionary genetics, quantitative genetics, experimental evolution and artificial selection, molecular genetics, physiology and genomics in the fruit fly (Drosophila melanogaster) and closely related species.

Representative publications

21634052, 20970491, 20865043, 20854888, 22913798

Research keywords

Life history evolution, evolution and mechanisms of aging, evolutionary physiology, endocrine regulation, trade-offs, pleiotropy, costs of reproduction, genotype-phenotype map, natural variation, experimental evolution, Drosophila.

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Latitude and Longitude

48.2084671,16.3730908