Alexander Stark

@stark
active 3 years, 8 months ago

Base

Full Name

Alexander Stark

Current position

Group leader

Affiliation

IMP

Location

Austria

Research interests

We are interested in how gene regulatory information is encoded in the genomic DNA sequence.

Using a combination of systematic genome-wide experiments and bioinformatics, we are aiming to understand the sequence basis of cell-type specific enhancer function, to predict expression from the sequence, and to ultimately build synthetic enhancers of defined activity.

Webpage

http://www.starklab.org

Research activity

Research

The regulation of gene expression in response to developmental or environmental stimuli is a crucial process in all organisms. Transcription is regulated by trans-acting transcription factors that recognize cis-regulatory DNA elements (CRMs or enhancers) and function in a combinatorial fashion. Enhancers retain their activity even when placed in artificial contexts (e.g. in reporter gene assays), but the exact requirements for enhancer function, i.e. a regulatory code, remains unknown and enhancer activity cannot be predicted from the DNA sequence.

Representative publications

22534400, 22499593, 22179591, 21478888, 20045679, 19920814, 19913403, 17994088, 17989251

Research keywords

regulatory genomics, gene expression, transcription factors, computational biology, regulatory code

Job openings

Advanced

Latitude and Longitude

47.2000338,13.199959