We are interested in how gene regulatory information is encoded in the genomic DNA sequence.
Using a combination of systematic genome-wide experiments and bioinformatics, we are aiming to understand the sequence basis of cell-type specific enhancer function, to predict expression from the sequence, and to ultimately build synthetic enhancers of defined activity.
The regulation of gene expression in response to developmental or environmental stimuli is a crucial process in all organisms. Transcription is regulated by trans-acting transcription factors that recognize cis-regulatory DNA elements (CRMs or enhancers) and function in a combinatorial fashion. Enhancers retain their activity even when placed in artificial contexts (e.g. in reporter gene assays), but the exact requirements for enhancer function, i.e. a regulatory code, remains unknown and enhancer activity cannot be predicted from the DNA sequence.
22534400, 22499593, 22179591, 21478888, 20045679, 19920814, 19913403, 17994088, 17989251
regulatory genomics, gene expression, transcription factors, computational biology, regulatory code
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