MRC-Laboratory of Molecular Biology
Cambridge, United Kingdom
Regulation of cell shape by the cytoskeleton during tissue morphogenesis
Regulation of cell shape by the cytoskeleton during development and tissue morphogenesis
The formation of different tissues from sheets of epithelial cells involves individual cell shape changes, driven by the intracellular cytoskeleton, that are integrated to contribute to the overall change in tissue shape. Many of the gene regulatory networks that specify tissue identity have been uncovered, but how the collection of genes expressed leads to the complex shape changes that drive morphogenesis is not well understood. We use a tractable invertebrate model system, Drosophila, as our ‘tissue culture incubator’ in combination with state-of-the-art live and high resolution imaging approaches, to acquire a better understanding of the guiding principles of tissue morphogenesis by bridging the differing scales between molecular (cytoskeletal), cellular and tissue behaviour.
23153493, 20150280, 19064711, 17327273
cytoskeleton, cytolinker, morphogenesis, cell shape, Drosophila, Crumbs, microtubules, actin, tissue mechanics, polarity, epithelial tubes, tubulogenesis
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