MRC Functional Genomics Unit, University of Oxford
Oxford, United Kingdom
Intracellular Compartmentation in Drosophila
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Intracellular compartments such as organelles are essential for a cell’s function. RNA occurs in every compartment in a cell. Research in the Liu group focuses on three fundamental questions relating to RNA, for which we seek an in vivo understanding. We choose the fruitfly Drosophila melanogaster as our prime model system because of its genetic tractability and the depth of genomic data. Studies in Drosophila have provided a key to vertebrate development and human biology.
First, we will study the mechanisms by which the synthesis of CTP, one of the critical precursors of RNA and DNA, is compartmentalized within a cell. We have recently discovered that CTP synthase is compartmentalized in a novel evolutionarily conserved organelle, the cytoophidium. Compartmentation is essential for the localization of biological processes within a eukaryotic cell. CTP synthase has been an attractive target for developing agents against cancer, virus and parasites. We will investigate how CTP synthase is assembled into the cytoophidium and how the cytoophidium is linked to cancer biology.
23827738, 22445511, 21490958, 21254152, 20513629, 19158395
Cytoophidium, CTP synthase, survival motor neuron, noncoding RNA, oogenesis, stem cell
PhD studentships are available.
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