Máximo Ibo Galindo
Centro de Investigación Príncipe Felipe
We are interested in the interplay of planar cell polarity and cell signalling, using the developing Drosophila leg as a model,
|Google Scholar Profile|
In our group we are currently working in two research projects focused in cellular aspects of Developmental Biology and in the development of a Drosophila model of human disease.
In the first project ,we are studying the interplay of planar cell polarity and cell signalling through the Notch pathway. During leg development, the planar polarisation of the epithelium restricts directionality of Notch signalling, such as only cells distal to the source of the Serrate ligand can respond to it. In planar polarity mutants this restriction is lost. Our work has revealed that proximal repression is achieved by asymmetrical localisation of Dishevelled and direct Dishevelled-Notch interaction, and involves endocytic control of the Notch receptor. Our next goal is to expand our focus to study the interaction and cross regulation of these two pathways with EGFR signalling, and the role of leg segmental boundaries as organisers of cellular signalling.
We got involved in the second project though collaboration with another group at the institute, the Genetics and Molecular Medicine Unit led by Prof. Francesc Palau. Prof. Palau is also Scientific Director of the Centre for Biomedical Network Research on Rare Diseases (CIBERER). This group´s interest is the genetics and pathophysiology of inherited peripheral neuropathies, mainly those forms of the Charcot-Marie-Tooth (CMT) disease which are related to mitochondrial dynamics. We are developing a Drosophila model to study neurodegeneration caused by altered expression of genes involved in mitochondrial dynamics. Our preliminary results indicate that the fly is a suitable model to study this type of neurodegeneration and offers a good opportunity to get an insight into the pathophysiology of CMT.
22736244, 21320482, 21079739, 19744956
Notch, EGFR, planar cell polarity, disease models, developmental biology.
|Latitude and Longitude||