Cancer Research UK – London Research Institute
London, United Kingdom
Tissue growth and form in Drosophila
The Epithelial Biology Lab uses Drosophila as a model organism to explore how cells co-operate to construct epithelial tissues during development and how epithelial tumours can arise. We focus on the question of how cell polarity organises the behaviour of cells within an epithelium.
We take three main approaches:
1. Genome-wide in vivo RNAi screening;
2. Live-imaging of epithelial tissue development;
3. Computational modelling of cell polarity and cell behaviour.
We aim to combine these approaches to identify molecular mechanisms responsible for organising cell polarity and cell behaviour during tissue growth and morphogenesis in epithelia. Our recent work has examined two different types of cell polarity in epithelia, apico-basal polarity and planar polarity.
22658591, 21245166, 20833011, 16923395
Drosophila, cell polarity, epithelia, apico-basal polarity, planar cell polarity, cell proliferation, Hippo signalling.
I have two fully funded 4 year Post-doctoral fellowships available in my laboratory to start at any time.
|Latitude and Longitude||