Bart Deplancke

@bart
active 2 years, 11 months ago

Base

Full Name

Bart Deplancke

Current position

Assistant Professor

Affiliation

EPFL (Swiss Federal Institute of Technology, Lausanne)

Location

Lausanne, Switzerland

Research interests

The goal of our research program is to elucidate the metazoan gene regulatory code and to examine how variations in this code affect phenotypic diversity using Drosophila as one of our principal model organisms.

Webpage

http://deplanckelab.epfl.ch/

Research activity

Research

The central aims of my Lab are to elucidate the metazoan gene regulatory code and to examine how variations in this code affect phenotypic diversity. Specifically, we are engaged into two major Drosophila research projects. The first aims to elucidate the gene regulatory networks underlying wing imaginal disc development. The second aims to use genetic variation as an organic tool to dissect the regulatory architecture of the genome. As part of the first project, we have recently developed a yeast and microfluidics-based platform, which enables the high-throughput, DNA-centered identification and mapping of transcription factor-DNA interactions within regulatory elements using an almost complete array of full-length, sequence-verified Drosophila transcription factor clones (Hens et al., Nature Methods, 2011). In the second project, we have recently developed a novel algorithm to detect and assemble non-SNP variants at single nucleotide resolution (Massouras et al., Nature Methods, 2010). We are currently using this algorithm to study genomic variation in inbred fly lines from the Drosophila Genetic Reference Panel.

Representative publications

20501601, 20543844, 22037703, 22223795

Research keywords

Gene regulatory networks, systems genetics, genomic variation, gene expression, genotype, phenotype, transcription factor, RNA-seq

Job openings

Always interested in great candidates!

Advanced

Latitude and Longitude

46.51939,6.56673