EPFL (Swiss Federal Institute of Technology, Lausanne)
The goal of our research program is to elucidate the metazoan gene regulatory code and to examine how variations in this code affect phenotypic diversity using Drosophila as one of our principal model organisms.
The central aims of my Lab are to elucidate the metazoan gene regulatory code and to examine how variations in this code affect phenotypic diversity. Specifically, we are engaged into two major Drosophila research projects. The first aims to elucidate the gene regulatory networks underlying wing imaginal disc development. The second aims to use genetic variation as an organic tool to dissect the regulatory architecture of the genome. As part of the first project, we have recently developed a yeast and microfluidics-based platform, which enables the high-throughput, DNA-centered identification and mapping of transcription factor-DNA interactions within regulatory elements using an almost complete array of full-length, sequence-verified Drosophila transcription factor clones (Hens et al., Nature Methods, 2011). In the second project, we have recently developed a novel algorithm to detect and assemble non-SNP variants at single nucleotide resolution (Massouras et al., Nature Methods, 2010). We are currently using this algorithm to study genomic variation in inbred fly lines from the Drosophila Genetic Reference Panel.
20501601, 20543844, 22037703, 22223795
Gene regulatory networks, systems genetics, genomic variation, gene expression, genotype, phenotype, transcription factor, RNA-seq
Always interested in great candidates!
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