Our group is interested in the essential regulatory processes that control and maintain neuronal activity and which malfunction cause diseases like epilepsy, Alzheimer’s and ALS.
As a model, we investigate the olfactory system, which has a simple cellular logic that is conserved from flies to humans. Our approach is to do the discoveries in the experimentally highly accessible and numerical simple fruit fly system and to establish the evolutionary conservation of the identified mechanisms in the much more elaborate mouse system. We take a multidisciplinary experimental approach, including Drosophila and mouse genomic tools, single cell approaches, behavior analysis, biochemistry and live cell imaging in combination with cryo-EM and cutting-edge neuroscience methodologies.
Olfaction, odorant receptors, gene regulation, olfactory sensory neurons, neuronal specification, axon guidance, nueonal activity regulation
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