Inhibiting Parkinson-related LRRK2 kinase activity not such a great idea?
We published a paper in Neuron showing that LRRK2/LRRK, a protein mutated in Parkinson patients, directly phosphorylates EndophilinA, a protein critical for synaptic endocytosis. The most commonly found mutation in LRRK2, a G2019S transition causes increased kinase activity, but numerous other mutations exist as well. We show that LRRK...
